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Antibiotics are complex macromolecular compounds obtained by a natural, semisynthetic or synthetic means, which have bactericidal or bacteriostatic action on pathogens. Antibiotics are commonly used as etiologic agents for the treatment of infectious and non-infectious diseases caused by bacteria, rickettsiae, chlamydiae, mycoplasmas and fungi.
Several thousands of antibiotic, but in practical use about 100 of them.
Classification according to chemical structure:
Penicillins have a narrow spectrum of activity have bactericidal activity by inhibiting the synthesis of cell wall and cause osmotic bakterioliza. Acting mainly on gram-positive microorganisms.
Penicillin with a broad spectrum of activity are aminopenicillins, ureidopenitsilini and karboksipenitsilini.
Bactericidal cephalosporin act by disrupting cell wall synthesis. Possess a broad spectrum of activity against gram positive and gram negative microorganisms.
Bactericidal aminoglycosides act by interfering with protein synthesis mainly of gram negative bacteria
Bacteriostatic tetracyclines act by blocking protein synthesis in susceptible microorganisms. At high doses can act bactericidal. Better penetrate the tissues and cells and are effective against intracellular pathogens.
Macrolides are cyclic lactones, amines and neutral sugar. Bacteriostatic act by inhibiting protein synthesis.